Catalog Number - 40008-PG2

The 40008‑PG2 Cogent Bidentate C8 Guard Column Cartridges are replacement cartridges designed to protect analytical HPLC columns from particulates, strongly retained compounds, and sample matrix contamination.

Each cartridge is:

• 2.0 mm ID × 10 mm length

• Packed with 4 µm, 100 Å TYPE‑C™ silica hydride Bidentate C8 phase

• Constructed in stainless steel hardware with SS frits

Cartridges are individually packaged in protective Delrin™ cases, preventing drying, contamination, and physical damage prior to use.

⚠️ Requires guard column holder (sold separately)

Designed for 2.1 mm Analytical Columns

These guard cartridges are optimized for:

• 2.1 mm ID analytical HPLC columns

• LC‑MS systems and low‑flow methods

• High‑sensitivity analytical workflows

Using properly matched guard cartridges ensures:

• Minimal impact on peak shape

• Preserved chromatographic efficiency

• Consistent retention and selectivity

Why Use Replacement Guard Cartridges

Analytical columns are exposed to:

• Particulates from samples and solvents

• Strongly retained or irreversible contaminants

• Matrix buildup from complex samples

The 40008‑PG2 cartridges function as a sacrificial protection layer, helping to:

• Extend analytical column lifetime

• Prevent irreversible column fouling

• Improve reproducibility between runs

• Reduce operating cost per analysis

Cartridges can be replaced quickly without disturbing the analytical column, maintaining uptime and performance.

Bidentate C8 Guard Phase Matching

Using the same phase as your analytical column ensures:

• No change in selectivity or retention behavior

• Seamless analyte transfer to the column

• No need for method re‑optimization

Compared to C18 phases, Bidentate C8:

• Reduces excessive hydrophobic retention

• Improves recovery of amine‑containing compounds

• Provides alternative selectivity for complex mixtures

• Supports faster equilibration

Cogent TYPE‑C™ Advantages

Silica Hydride Surface

• Reduced silanol activity

• Improved peak shape for basic analytes

• Lower secondary interactions

Fast Equilibration

• Shorter cycle times

• Improved analytical throughput

Durability

• Resistant to hydrolysis

• Long cartridge lifetime

• Consistent performance under routine use

Typical Applications

• LC‑MS analytical methods

• Pharmaceutical and metabolite analysis

• Samples with complex matrices or contaminants

• Amine‑containing compounds

• Routine HPLC workflows requiring column protection